Study of Drug Interactions with Membranes is Monthly Publication Highlight

Nov 25, 2013

A research project that sheds important light on models of drug binding to membranes has been named the UK College of Pharmacy Research Publication Highlight for November. The research was published in the Journal of Pharmaceutical Research and is entitled, “Bilayer Composition, Temperature, Speciation Effects and the Role of Bilayer Chain Ordering on Partitioning of Dexamethasone and its 21-Phosphate.”

This work was conducted by Dr. Sweta Modi, a recent graduate from the laboratory of Dr. Brad Anderson, the H.B. Kostenbauder Professor in the Department of Pharmaceutical Sciences in the College of Pharmacy.

The partitioning of drugs into membranes is one of the important factors governing in vivo drug distribution and bioaccumulation. Quantitative models of drug partitioning into lipid bilayers are also needed to design liposomal nanoparticles with controllable rates of drug release. This new research describes theoretical and practical considerations to be taken into account for neutral and ionized molecules in accurately determining their membrane-water partition coefficient values. The study explores the partitioning of two model compounds in liposomes varying in structure, physical state, and pH and develops a model for prediction in other similar systems. These results will facilitate the development of more comprehensive models to predict rates of drug release from liposomal drug delivery systems and advance understanding of drug distribution in the body.

“This research from the Anderson Laboratory will help to develop delivery systems to enhance the efficacy and safety of the next generation of pharmacotherapeutics,” said Linda Dwoskin, Associate Dean for Research for the UK College of Pharmacy. “This is a great example of how our pharmaceutical scientists add great value to the drug discovery and development process and move new drugs towards clinical trials for evaluation of safety and efficacy in human subjects.”

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