ABOUT
Brad Anderson - PH.D.
Bradley D. Anderson is the H.B. Kostenbauder Professor, Division of Pharmaceutical Sciences at the University of Kentucky. He received a B.A. in chemistry (1971) and M.S. and Ph.D. degrees in Pharmaceutical Chemistry (1978) from the University of Kansas. He was a research scientist at The Upjohn Company for 5 years prior to joining the University of Utah in 1983 where he was a Professor of Pharmaceutics & Pharmaceutical Chemistry until March of 2000. He then relocated to the University of Kentucky where he served as Chair of the Division of Pharmaceutical Sciences until 2003.
He is a Charter Member and Fellow of the American Association of Pharmaceutical Scientists (AAPS). He has received the Pfizer Young Investigator Award (1985), the Meritorious Manuscript Award from Pharmaceutical Research (1990), the Outstanding Paper Award in the Journal of Controlled Release (1992), the Ebert Prize for the best paper in the Journal of Pharmaceutical Sciences (1998), and the University of Utah Distinguished Research Award (1999).
He serves on the editorial advisory boards for Pharmaceutical Research, International Journal of Pharmaceutics, Pharmaceutical Development and Technology, Biopharmaceutics and Drug Disposition, Journal of Pharmaceutical Sciences and AAPS PharmSci and is an Associate Editor for the Journal of Pharmaceutical Sciences. Dr. Anderson has been a regular member and chair of the NIH Pharmacology Study Section. He has received several patents in prodrug design and drug formulation and has published over 100 research articles and patents in the kinetics of drug and protein degradation, prodrug design, solution and solid state thermodynamic properties of drugs, biomembrane and lipid bilayer transport, and drug delivery.
Selected Honors
- Robert A. Blouin Excellence in Pharmaceutical Graduate Education Award for Academic Year (2004-05)
- University of Utah Distinguished Research Award (1999)
- Ebert Prize (best paper in Journal of Pharmaceutical Sciences) (1998)
- Appointed Chair, NIH Pharmacology Study Section, (1997-99) (regular member 1995-1999)
Selected Publications/Presentations
- T.-X. Xiang, Z.-Q. Jiang, and B.D. Anderson, Molecular dynamics simulations and experimental studies of binding and mobility of 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67) and its 20(S)-4-aminobutyrate ester in DMPC membranes, Molecular Pharmaceutics, in press.
- R.S. Tangirala, S. Antony, K. Agama, Y. Pommier, B.D. Anderson, R. Bevins, and D.P. Curran, Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin, Bioorg Med Chem. 14, 6202-12 (2006).
- L. Song, R. Bevins, and B.D. Anderson, Kinetics and mechanisms of activation of a-amino acid ester prodrugs of camptothecins, J. Med. Chem., 49, 4344-4355 (2006).
- B.D. Anderson, M.J. Crump, S. Jordan, L. Song, M.J. Roberts, and M. Leggas, Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats, Drug Metab. Disp. 34, 653-659 (2006).
- B.D. Anderson and D. Luo, Application of an exact mathematical model and the steady-state approximation to the kinetics of the reaction of cysteine and hydrogen peroxide in aqueous solution: A reply to the Ashby and Nagy commentary, J. Pharm. Sci., 95, 19-24 (2006).
- T.-X. Xiang and B.D. Anderson, Conformational structure, dynamics and solvation energies of small alanine peptides in water and carbon tetrachloride, J. Pharm. Sci., 95, 1269-1287 (2006).
- T.-X. Xiang and B.D. Anderson, Distribution and effect of water content on molecular mobility in poly(vinylpyrrolidone) glasses: A molecular dynamics simulation, Pharm. Res., 22, 1205-1214 (2005).
- J.E. Edwards, J. Alcorn, J. Savolainen, B.D. Anderson, and P.J. McNamara, Role of p-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier, Antimicrob. Agents Chemother., 49, 1626-28 (2005).
- Burke, T.G., T.-X. Xiang, B.D. Anderson, and L.J. Latus. "Recent Advances in Camptothecin Drug Design and Delivery Strategies" in Camptothecins in Cancer Therapy, T.G. Burke and V.R. Adams, Eds., Humana Press, Inc., New Jersey (2005).
- D. Luo, S.W. Smith, and B.D. Anderson, Kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solution, J. Pharm. Sci., 94, 304-316 (2005).