Brad Anderson

Contact Information

College of Pharmacy
A323A ASTeCC Building
Lexington, KY 40506-0286

phone: 859-218-6536

Contact by email

Positions

  • Director, Division of Drug Development
    Department of Pharmaceutical Sciences
  • Professor
    Department of Pharmaceutical Sciences

 

 

Bradley D. Anderson - PH.D.

Dr. Anderson is the H.B. Kostenbauder Professor in Pharmaceutical Sciences, College of Pharmacy, University of Kentucky.  He received his Ph.D. in Pharmaceutical Chemistry (1978) from the University of Kansas.  He was a research scientist at The Upjohn Co. for 5 years prior to joining the University of Utah in 1983.  In 2000 he relocated to the University of Kentucky where he served as Chair of Pharmaceutical Sciences until 2003 and is currently Director of the Division of Drug Development in the College of Pharmacy.

He is a Charter Member of the AAPS and an AAPS Fellow.  In 1985 Dr. Anderson received the Pfizer Young Investigator Award (1985).  He has received several awards, including the Meritorious Manuscript Award from Pharm. Res. (1990), the Outstanding Paper Award in J. Controlled Release (1992), the Ebert Prize for the best paper in J. Pharm. Sci. (1998), and the University of Utah Distinguished Research Award (1999).  Dr. Anderson serves on several editorial advisory boards and is an Associate Editor for J. Pharm. Sci.  He holds several patents in prodrug design and drug formulation design and has approximately 130 publications in drug solubilization and stabilization, prodrug design and drug targeting, lipid bilayer transport and liposomal drug delivery, and computational methods for predicting molecular properties.

Selected Honors

  • Robert A. Blouin Excellence in Pharmaceutical Graduate Education Award for Academic Year (2004-05)
  • University of Utah Distinguished Research Award (1999)
  • Ebert Prize (best paper in Journal of Pharmaceutical Sciences) (1998)
  • Appointed Chair, NIH Pharmacology Study Section, (1997-99) (regular member 1995-1999)

Selected Publications/Presentations

  • M. DeHart and B.D. Anderson, The Role of the Cyclic Imide in Alternate Degradation Pathways for Asparagine-Containing Peptides and Proteins, J. Pharm. Sci., 96, 2667-2685 (2007).

  • V. Joguparthi, T.-X. Xiang, and B.D. Anderson, Liposome Transport of Hydrophobic Drugs:  Gel Phase Lipid Bilayer Permeability and Partitioning of the Lactone Form of a Hydrophobic Camptothecin, DB-67, J. Pharm. Sci., 97, 400-420 (2008).

  • V. Joguparthi and B.D. Anderson, Liposomal Delivery of Hydrophobic Weak Acids:  Enhancement of Drug Retention Using a High Intraliposomal pH, J. Pharm. Sci., 97, 433-454 (2008). 

  • V. Joguparthi, S. Feng, and B.D. Anderson, Determination of Intraliposomal pH and Its Effect on Membrane Partitioning and Passive Loading of a Hydrophobic Camptothecin, DB-67, Int. J. Pharm., 352, 17-28 (2008).

  • D. Luo and B.D. Anderson, Application of a Two-State Kinetic Model to the Heterogeneous Kinetics of Reaction between Cysteine and Hydrogen Peroxide in Amorphous Lyophiles, J. Pharm. Sci., 97, 3907-26 (2008).

  • S. Rane, Y. Cao, and B.D. Anderson, Quantitative Solubility Relationships and the Effect of Water Uptake in Triglyceride/Monoglyceride Microemulsions, Pharm. Res., 25, 1158-1174 (2008).

  • S. Rane and B.D. Anderson, What Determines Drug Solubility in Lipid Vehicles:  Is it Predictable?, Adv. Drug Delivery Rev., 60, 638-656 (2008).

  • Y. Cao, T.-X. Xiang, and B.D. Anderson, Development of Structure-Lipid Bilayer Permeability Relationships for Peptide-Like Small Organic Molecules, Molecular Pharmaceutics, 5, 371-388 (2008).

  • R.W. Tejwani and B.D. Anderson, Substituent Effects on the Ionization and Partitioning of p-(Aminoethyl)phenols and Structurally Related Compounds, J. Pharm. Sci., 98, 4534-4544 (2009).

  • D.D. Patel, V. Joguparthi, Z. Wang and B.D. Anderson, Maintenance of Supersaturation: 1. Indomethacin Crystal Growth Kinetic Modeling Using an Online Second Derivative UV Spectroscopic Method, J. Pharm. Sci., 100, 2623-41 (2011).

  • R.W. Tejwani, M.E. Davis, B.D. Anderson, T.R. Stouch, Functional Group Dependence of Solute Partitioning to Various Locations in a DOPC Bilayer: I. A Comparison of Molecular Dynamics Simulations with Experiment, J. Pharm. Sci., 100, 2636-46 (2011).

  • R.W. Tejwani, M.E. Davis, B.D. Anderson, T.R. Stouch, An Atomic and Molecular View of the Depth Dependence of the Free Energies of Solute Transfer from Water into Lipid Bilayers, Molecular Pharmaceutics, 8, 2204-2215 (2011).

  • M. P. DeHart and B.D. Anderson, Kinetics and Mechanisms of Deamidation and Covalent Amide-Linked Adduct Formation in Amorphous Lyophiles of a Model Asparagine-Containing Peptide, Pharm. Res., 29, 2722-2737 (2012).

  • E.D. Adane, Z. Liu, T.-X. Xiang, B.D. Anderson and M. Leggas, Pharmacokinetic Modeling to Assess Factors Affecting the Oral Bioavailability of the Lactone and Carboxylate Forms of the Lipophilic Camptothecin Analogue AR-67 in Rats, Pharm. Res., 29, 1722-1736 (2012).

  • M.P. DeHart and B.D. Anderson, A Mechanism-Based Kinetic Analysis of Succinimide Mediated Deamidation, Racemization, and Covalent Adduct Formation in a Model Peptide in Amorphous Lyophiles, J. Pharm. Sci., 101, 3096-3109 (2012).

  • M.P. DeHart and B.D. Anderson, Effects of Water and Polymer Content on Covalent Amide-Linked Adduct Formation in Amorphous Lyophiles, J. Pharm. Sci., 101, 3142-3156 (2012).

  • S. Modi, T.-X. Xiang, and B.D. Anderson, Enhanced Active Liposomal Loading of a Poorly Soluble Ionizable Drug Using Supersaturated Drug Solutions, J. Controlled Rel., 162, 330-339 (2012).

  • T.X. Xiang and B.D. Anderson, Molecular Dynamics Simulation of Amorphous Indomethacin, Molecular Pharmaceutics, 10, 102-114 (2013).

  • B.D. Anderson, The State of Water and Its Impact in Pharmaceutical Systems: Lipid-Based Drug Delivery Systems and Amorphous Solids, In, Water Stress in Biological, Chemical,Pharmaceutical and Food Systems: ISOPOW 11, G. Gutiérrez and L. Alamilla, Eds., Springer, in press.

  • T.X. Xiang and B.D. Anderson, “Molecular Dynamics Simulation of Amorphous Indomethacin-PVP Glasses:  Solubility and Hydrogen Bonding Interactions”, J. Pharm. Sci., 102, 876-891 (2013).

  • H-S Lin, V.M. Sviripa, D.S. Watt, C. Liu, T.X. Xiang, B.D. Anderson, P.S. Ong, and P.C. Ho, Quantification of trans-2,6-Difluoro-4’-N,N-dimethylaminostilbene in Rat Plasma: Application to a Pharmacokinetic Study, Journal of Pharmaceutical and Biomedical Analysis, 72, 115-120 (2013).

  • D.D. Patel, B.D. Anderson, “Maintenance of supersaturation II: indomethacin crystal growth kinetics versus degree of supersaturation”, J Pharm Sci, 102, 1544-1553 (2013).

  • S. Modi, B.D. Anderson, “Determination of drug release kinetics from nanoparticles: overcoming pitfalls of the dynamic dialysis method”, Mol Pharm, 10, 3076-3089 (2013).

  • S. Modi, B.D. Anderson, “Bilayer Composition, Temperature, Speciation Effects and the Role of Bilayer Chain Ordering on Partitioning of Dexamethasone and its 21-Phosphate”, Pharm Res, in press

Website links

page last modified: October 07 2013     

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