Contact Information

331 College of Pharmacy
789 S. Limestone St.
Lexington, KY 40536-0596

Phone: 859-257-1571
Fax: 859-257-7564

Contact by email

Positions

• Assistant Professor
  Department of Pharmaceutical Sciences
• Associate Member
  Pharmaceutical Sciences Graduate Faculty
  University of Kentucky Graduate School
• Adjunct Faculty Member
  Graduate School-Pharmaceutical Sciences
  University of North Carolina-Chapel Hill
• Faculty Associate
  UK Center of Membrane Sciences
  University of Kentucky

Education

• B.S., Pharmacy
  University of Wisconsin-Madison, 1996
• Ph.D. Minor: Advanced Physical and Biophysical Chemistry
  University of Wisconsin-Madison, 1999
• Ph.D., Pharmaceutical Sciences (Ph.D. Major: Drug Delivery & Pharmaceutics)
  University of Wisconsin-Madison, 2003
• Post-Doctoral Scholar
  University of Wisconsin-Madison, 2004
• Post-Doctoral Scholar & Fellow
  University of North Carolina-Chapel Hill, School of Pharmacy, 2006-2008

Heidi Mansour - Ph.D.

Dr. Mansour's research focuses on the application of interfacial phenomena and biocolloidal chemistry in the design of advanced drug delivery self-assembly systems and development of pulmonary inhalation aerosols for targeted lung drug delivery (pulmonary disease treatment) and for novel needle-free vaccine inhalation aerosol delivery (pulmonary disease prevention) as multifunctional microparticles and nanoparticles. In addition, she has an active research program on sustained-release injectable depot delivery of therapeutic polypeptides encapsulated in biodegradable/biocompatible polymeric microspheres and nanoparticles for controlled drug delivery over several weeks to months (following a single depot injection) for the treatment of various disease states.

She earned a B.S. in pharmacy (1996) and a Ph.D. in pharmaceutical sciences (2003) from the University of Wisconsin at Madison. Dr. Mansour recently was honored during the 2007 American Association of Pharmaceutical Scientists annual meeting in San Diego, receiving the PhRMA Postdoctoral Fellow Award in Pharmaceutics and the AAPS Postdoctoral Fellow Award for research excellence.

Prior to her appointment at UK, she was an Instructor (both in the Graduate and Pharm.D. Programs) and a postdoctoral fellow at the University of North Carolina at Chapel Hill, School of Pharmacy, in the Division of Molecular Pharmaceutics, receiving the 2007 UNC-Chapel Hill Postdoctoral Award for Research Excellence from the Office of the Vice Chancellor.

Selected Honors

• Mercer School of Pharmacy, Department of Pharmaceutical Sciences, Pharmabeat 2010 "Researcher of the Issue", Mercer University, 2010
• Scholarship of Teaching & Learning Certificate (STLC) Award, UK College of Pharmacy, University of Kentucky, 2010
• UNC-Chapel Hill Vice Chancellor’s Post-Doctoral Scholar Award in Research Excellence, 2007-2008
• American Association of Pharmaceutical Scientists (AAPS) Post-Doctoral Fellow Award in Research Excellence, 2007
• PhRMA Foundation Post-Doctoral Fellow Award in Pharmaceutics, 2007
• National Institutes of Health (NIH)-UNC-Chapel Hill Regional Training Award Scholar, 2007
• Walter F. Enz Award in Research Excellence in the Pharmaceutical Sciences, Pharmacia Global Pharmaceutical Sciences, 2001
• PhRMA Foundation Advanced Pre-Doctoral Fellow Award in Pharmaceutics, 2000-2002
• AFPE Pre-Doctoral Fellow Award in Pharmaceutics, 1999-2001
• Merck Award in Excellence in Pharmacy, 1996
• Rho Chi Pharmaceutical Honor Society Award for Academic Excellence, 1994
• University of Wisconsin-Madison Chemistry Enrichment Award, 1992
• Wisconsin Academic Excellence Scholar, 1991-1995
• Rho Chi Pharmaceutical Honor Society, Elected Member
• Golden Key International Honor Society, Elected Member
• Phi Kappa Phi National Honor Society, Elected Member
• Phi Eta Sigma National Honor Society, Elected Member

Selected Journal Publications

• Wu, X., Zhang, W., Hayes, D. Jr., and Mansour, H.M. Physicochemical Characterization and Aerosol Dispersion Performance of Organic Solution Advanced Spray-Dried Cyclosporine A Multifunctional Particles for Dry Powder Inhalation Aerosol Delivery. International Journal of Nanomedicine (2013) 8: 1269-1283. [link]
• Wu, X., Hayes, D. Jr., Zwischenberger, J.B., Kuhn, R.J., and Mansour, H.M. Design and Physicochemical Characterization of Advanced Spray-Dried Tacrolimus Multifunctional Particles for Inhalation. Drug Design, Development, and Therapy (2013)7: 59-72. [link]
• Meenach, S.A., Vogt, F.G., Anderson, K.W., Hilt, J.Z., McGarry, R.C., and Mansour, H.M. Design, Physicochemical Characterization, and Optimization of Organic Solution Advanced Spray-Dried Inhalable Dipalmitoylphosphatidylcholine (DPPC) and Dipalmitoylphosphatidylethanolamine Poly(Ethylene Glycol) (DPPE-PEG) Microparticles and Nanoparticles for Targeted Respiratory Nanomedicine Delivery as Dry Powder Inhalation Aerosols. International Journal of Nanomedicine (2013) 8:275-293. [link]
• Mansour, H.M. Aerosol Formulation Issues. Pediatric Pulmonology (2012) 47 (35):149-151. [link]
• Park, C.W., Mansour, H.M., Oh, T.O., Kim, J.Y., Ha, J.M., Lee, B.J., Chi, S.C., Rhee, Y.S., Park, E,S. Phase Behavior of Itraconazole-Phenol Mixtures and Its Pharmaceutical Applications. International Journal of Pharmaceutics  (2012) 436 (1-2):652-658. [link]
• Willis, L, Hayes, D. Jr., and Mansour, H.M. Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery. Lung  (2012): 190 (3): 251-262.[link] [reprint cover page]
• Park, C.W., Rhee, Y.S., Vogt, F.G., Hayes, D Jr., Zwischenberger, J.B., DeLuca, P.P., and Mansour, H.M. Advances in Microscopy and Complementary Imaging Techniques to Assess the Fate of Drugs Ex-Vivo in Respiratory Drug Delivery. An Invited Paper. Advanced Drug Delivery Reviews: Special Theme Issue-Computational and Visualization Approaches in Respiratory Delivery (2012) 64 (4): 344-356. [link]
• Duan, J.H., Mansour, H.M., Zhang, Y.D., Deng, X.M., Zhao, J.F. Reversion of Multi-Drug Resistance by Co-Encapsulation of Doxorubicin and Curcumin in Chitosan/poly(butylcyanoacrylate) Nanoparticles. International Journal of Pharmaceutics(2012) 426 (1-2): 193-201. [link]
• Hayes, D. Jr., Kirkby, S., McCoy, K.S.,  Mansour, H.M., Khosravi, M., Strawbridge, H., and Tobias, J.D. Reduction of Lipid-Laden Macrophage Index After Laproscopic Nissen Fundoplication in Cystic Fibrosis Patients After Lung Transplantation. Clinical Transplantation (2012): IN PRESS [link]
• Hayes, D. Jr., Winkler, M.A., Kirkby, S., Capasso, P., Mansour, H.M. and Attili, A.K. Preprocedural Planning with Prospectively Triggered Multi-Detector Row CT Angiography prior to Bronchial Artery Embolization in Cystic Fibrosis Patients with Massive Hemoptysis. Lung (2012) 190 (2) April:221-225.[link]
• Hayes, D. Jr., Mansour, H.M., Kirkby, S., and Phillips, A.B. Rapid Acute Onset of Bronchiolitis Obliterans Syndrome in a Lung Transplant Recipient After Respiratory Syncytial Virus Infection. Transplant Infectious Diseases (2012): 1-3.[link]
• Hayes, D. Jr. and Mansour, H.M. Vanishing Bronchus Intermedius Syndrome in a Pediatric Patient with Cystic Fibrosis After Lung Transplantation. Pediatric Transplantation: The Official Journal of the International Pediatric Transplant Association (2012): 1-5. [link]
• Li, X. and Mansour, H.M. Physicochemical Characterization and Water Vapor Absorption of Organic Solution Advanced Spray Dried Trehalose Microparticles and Nanoparticles for Targeted Dry Powder Pulmonary Inhalation Delivery. AAPS PharmSciTech: Special Theme : Advances in Pharmaceutical Excipients Research and Use: Novel Materials, Functionalities and Testing (2011): 12 (4):1420-1430. [link] [reprint cover page]
• Rhee, Y.S., Sohn, M., Woo, B.H., Thanoo, B.C., DeLuca, P.P., and Mansour, H.M. Sustained-Release Delivery of Octreotide from Biodegradable Polymeric Microspheres. AAPS PharmSciTech: Special Theme -Sterile Products: Advances and Challenges in Formulation, Manufacturing, Devices and Regulatory Aspects.. (2011) 12 (4):1293-1301. [link] [reprint cover page]
• Hayes, D. Jr., Ball, A.M., Martin, C.A., Mansour, H.M., and Flynn, J.D. Fungal Infection in Heart-Lung Transplant Recipients Receiving Single-agent Prophylaxis With Itraconazole. Experimental and Clinical Transplantation  (2011) 9 (6): 399-404. [pdf].
• Hayes, D. Jr and Mansour, H.M. Improved Outcomes of Patients with End-Stage Cystic Fibrosis Requiring Invasive Mechanical Ventilation for Acute Respiratory Failure. Lung (2011) 189 (5): 409-415. [link] [reprint cover page]
• Mansour, H.M. Molecular Forces and Self Assembly in Colloid, Nano Sciences and Biology. Invited Paper. Journal of the American Chemical Society. (2011) 133 (13): 5162. [link]
• Park, C.W., Hayes, D. Jr., and Mansour, H.M. Pulmonary Inhalation Aerosols for Targeted Antibiotics Drug Delivery. Invited Paper. European Pharmaceutical Review. (2011) 16 (1): 32-36.[link]
• Rhee, Y.S. and Mansour, H.M. Nanopharmaceuticals I: Nanocarrier Systems in Drug Delivery. Invited Paper. International Journal of Nanotechnology: Special Issue- Nanopharmaceuticals. (2011) 8 (1/2): 84-114. [link]
• Wu, X. and Mansour, H.M. Nanopharmaceuticals II: Application of Nanoparticles and Nanocarrier Systems in Pharmaceutics and Nanomedicine. Invited Paper. International Journal of Nanotechnology: Special Issue- Nanopharmaceuticals. (2011)8 (1/2): 115-145. [link]
• Hayes, D. Jr.,  Zwischenberger, J.B., and Mansour, H.M. Aerosolized Tacrolimus: A Case Report in a Lung Transplant Recipient.  Transplantation Proceedings (2010)42 (9) November: 3876-3879. [link]
• Wu, X., Li, X., and  Mansour, H.M.  Surface Analytical Techniques in Solid-State Particle Characterization: Implications for Predicting Performance in Dry Powder Inhalers. Invited Paper. KONA Powder & Particle Journal. (2010) 28: 3-19. [pdf]
• Rhee, Y.S., Park, C.W., DeLuca, P.P., and Mansour, H.M. Sustained-Release Injectable Drug Delivery Systems. An Invited Paper.  Pharmaceutical Technology: Special Issue Supplement-Drug Delivery (2010) November: 6-13. [link]
• Mansour, H.M., Sohn, M., Al-Ghananeem, A., and DeLuca P.P. Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects. Invited Paper. International Journal of Molecular Sciences: Special Issue-Material Sciences and Nanotechnology Section - Biodegradability of Materials in Biomedical Applications (2010) 11: 3298-3322. [pdf]
• Mansour, H.M., Rhee, Y.S., and Wu, X. Nanomedicine in Pulmonary Delivery.  International Journal of Nanomedicine (2009) 4 December: 299-319. [pdf]
• Mansour, H.M. It's Only Natural: Using Polymers in Drug Delivery. Pharmaceutical Technology (2009) 33 (1) January: 1-2. [link]
• Xu, Z., Mansour, H.M., and Hickey, A.J. Particle Interactions in Dry Powder Inhaler Unit Processes. Journal of Adhesion Science and Technology: Special Issue on Adhesion Aspects in Pharmaceutical Sciences (2011): 25 (4/5) 451-482. [link]
• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Heterogenous Particle Deaggregation and Its Implications for Therapeutic Aerosol Performance. Journal of Pharmaceutical Sciences (2010) 99 (8) March 15: 3442-3461. [link]
•  Mansour, H.M., Xu, Z., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Alternative Sugar Blends: 3. Trehalose Dihydrate and D-Mannitol Carriers. Journal of Pharmaceutical Sciences (2010) 99 (8) March12; 3430-3441.[link]
• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Drug Blends with Lactose Monohydrate: 2. Ipratropium Bromide Monohydrate and Fluticasone Propionate. Journal of Pharmaceutical Sciences (2010) 99 (8) March 10: 3415-3429. [link]
• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Drug Blends with Lactose Monohydrate: 1. Albuterol Sulfate and Disodium Cromoglycate. Journal of Pharmaceutical Sciences (2010) 99 (8) March 2: 3398-3414. [link]
• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Comparative Dispersion Study of Dry Powder Aerosols of Albuterol Sulfate/Lactose Monohydrate and Cromolyn Sodium/Lactose Monohydrate Delivered by Standardized Entrainment Tubes. Respiratory Drug Delivery (2008) 3: 897-900. [link]
• Mansour, H.M. and Hickey, A.J. Raman Characterization and Chemical Imaging of Biocolloidal Self-Assemblies, Drug Delivery Systems, and Pulmonary Inhalation Aerosols. A Review. AAPS PharmSciTech (2007) 8 (4) November 30: Article 99:E1-E16. [pdf]
• Hickey, A.J., Mansour, H.M., et al. Physical Characterization of Component Particles Included in Dry Powder Inhalers: II. Dynamic Characteristics. Journal of Pharmaceutical Sciences: Special Issue David Grant Dedicated Issue (2007) 96 (5) May: 1302-1319. [link]
• Hickey, A.J., Mansour, H.M., et al. Physical Characterization of Component Particles Included in Dry Powder Inhalers: I. Strategy Review and Static Characteristics. Journal of Pharmaceutical Sciences: Special Issue David Grant Dedicated Issue (2007) 96 (5) May: 1282-1301. [link]
• Mansour H.M., Damodaran S., and Zografi G. Characterization of the In Situ Structural and Interfacial Properties of the Cationic Hydrophobic Heteropolypeptide, KL4, in Lung Surfactant Bilayer and Monolayer Models at the Air-Water Interface: Implications for Pulmonary Surfactant Delivery. Molecular Pharmaceutics (2008) 5 (5) October 6: 681-695. [link]
• Mansour, H.M. and Zografi G. Relationships Between Equilibrium Spreading Pressure and Phase Equilibria of Phospholipid Bilayers and Monolayers at the Air-Water Interface. Langmuir (2007) 23 (7) March 27: 3809-3819. [link
• Mansour, H.M. and Zografi G. The Relationship Between Water Vapor Absorption and Desorption by Phospholipids and Bilayer Phase Transitions. Journal of Pharmaceutical Sciences (2007) 96 (2) February: 377-396. [link]
• Mansour H., Wang D.-S., Chen C.-S., and Zografi G. Comparison of Bilayer and Monolayer Properties of Phospholipid Systems Containing Dipalmitoylphosphatidylglycerol and Dipalmitoylphosphatidylinositol. Langmuir (2001) 17 (21) October 16: 6622-6632. [link]

  Edited Book (Co-Editor)
  Nanomedicine in Drug Delivery.  Kumar, A., Mansour, H.M., Friedman, A., and Blough, E.R. (Editors), First Edition, CRC Press/Taylor & Francis, Inc. London, United Kingdom. (2012 in press). 450 pages. ISBN 9781466506169. [link]

  Book Chapters (Invited)
  Hickey, A.J. and Mansour, H.M. Book Volume 2, Chapter 43: Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols. Modified-Release Drug Delivery Technology Volume 2, Drugs and thePharmaceutical Sciences Series, Rathbone, M. J., Hadgraft, J., Roberts, M.S., Lane, M. E. (Editors), Second Edition,Informa Healthcare, New York, (2008): pp. 573-602. [link]

  Hickey, A.J. and Mansour, H.M. Book Volume 2, Chapter 5: Delivery of Drugs by the Pulmonary Route. Modern Pharmaceutics Volume 2: Applications and Advances, Drugs and the Pharmaceutical Sciences Series, Florence, A. T., Siepmann, J. (Editors), Fifth Edition, Informa Healthcare, New York, (2009): 191-219. [link]

  Mansour, H.M., Rhee, Y.S., Park, C.W., and DeLuca, P.P. Book Chapter 9: Lipid Nanoparticulate Drug Delivery and Nanomedicine. Lipids in Nanotechnology. 302 pages. Moghis, A. (Editor), First Edition, American Oil Chemists Society (AOCS) Press, Urbana, Illinois (2011) pp.221-268. [link]

  Mansour, H.M., Park, C.W., Bawa, R. Book Chapter 6: Design and Development of Approved NanopharmaceuticalProducts.  Handbook of Clinical Nanomedicine: From Bench to Bedside. Bawa, R., Audette, G., and Rubinstein, I. (Editors), First Edition, Pan Stanford Publishing/CRC Press/Taylor & Francis, Boca Raton, FL, (2012 in press ): 1-27. [link]

  Mansour, H.M.,  Park, C.W., and Hayes, D. Jr. Book Chapter 3: Nanoparticle Lung Delivery and Inhalation Aerosols for Targeted Pulmonary Nanomedicine. Nanomedicine in Drug Delivery. Kumar, A., Mansour, H.M., Friedman, A., and Blough, E.R. (Editors), First Edition, CRC Press/Taylor & Francis, Inc. London, United Kingdom. (2012) (in press). [link]

   Interview Articles
  DeLuca, P.P. and Mansour, H.M. Insight & Interview: Drug Delivery & Formulation-Controlled Release. World Pharmaceutical Frontiers (2011) 2 (September): 61-64. [pdf]

  Mansour, H.M. Insight & Interview: Meeting Manufacturing Challenges Tied to Extended-Release Injectables.Pharmaceutical Technology (2012) 36 (5): 40-47.[link]

  Website Links
  http://openwetware.org/wiki/User:Dr._Heidi_M._Mansour
  http://www.cntc.uky.edu/faculty/hmansour/
  http://igert.engr.uky.edu/participating-faculty/
  http://www.research.uky.edu/Membrane/faculty.html