Jim Pauly

Contact Information

College of Pharmacy
B451 Biomedical/Biological Sciences Research Building
741 South Limestone Street
Lexington, KY 40536

phone: 859-323-8164
fax: 859-257-7564

Contact by email

Positions

Professor and Director of Graduate Studies


Department of Pharmaceutical Sciences

 

Jim Pauly, Ph.D.

Dr. Pauly's research interests are primarily focused on the neurobiological actions of nicotine. The CNS nicotinic cholinergic system is studied using techniques that include quantitative receptor autoradiography, quantitative in situ hybridization histochemistry, ion flux assays and behavioral analyses. Dr. Pauly's lab is currently studying 1) the effects of prenatal nicotine exposure on brain development 2) the actions of steroid hormones (adrenal and ovarian) on the number and functional status of brain nicotinic receptor subtypes 3) the role of alpha 7 nicotinic receptors in regulating responsiveness to nicotine and 4) the brain nicotinic system in neurodegenerative conditions such as Alzheimer's and Parkinson's Disease. Dr. Pauly is also interested in the use of novel radioligands for the histochemical localization of receptor subtypes in the CNS as well as peripheral tissues such as the lung and heart.

Selected Publications/Presentations

  • Marshall SA, McClain JA, Kelso ML, Hopkins DM, Pauly JR, Nixon K. Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype. Neurobiol Dis. 2013 Jun;54:239-51. PMID:23313316
  • Rowe RK, Harrison JL, Thomas TC, Pauly JR, Adelson PD, Lifshitz J. Using anesthetics and analgesics in experimental traumatic brain injury. Lab Anim (NY). 2013 Aug;42(8):286-91. PMID:23877609
  • Cao T, Thomas TC, Ziebell JM, Pauly JR, Lifshitz J. Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat. Neuroscience. 2012 Dec 6;225:65-75. PMID:22960311
  • van Bregt DR, Thomas TC, Hinzman JM, Cao T, Liu M, Bing G, Gerhardt GA, Pauly JR, Lifshitz J. Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat. Exp Neurol. 2012 Mar;234(1):8-19. PMID:22178300
  • Readnower RD, Pandya JD, McEwen ML, Pauly JR, Springer JE, Sullivan PG. Post-injury administration of the mitochondrial permeability transition pore inhibitor, NIM811, is neuroprotective and improves cognition after traumatic brain injury in rats. J Neurotrauma. 2011 Sep;28(9):1845-53. PMID:21875332
  • Sauerbeck A, Gao J, Readnower R, Liu M, Pauly JR, Bing G, Sullivan PG. Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Exp Neurol. 2011 Jan;227(1):128-35. PMID:20965168
  • Kelso ML, Scheff NN, Scheff SW, Pauly JR. Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. Neurosci Lett. 2011 Jan 13;488(1):60-4. PMID:21056621
  • Kelso ML, Pauly JR. Therapeutic targets for neuroprotection and/or enhancement of functional recovery following traumatic brain injury. Prog Mol Biol Transl Sci. 2011;98:85-131. PMID:21199771
  • Readnower RD, Chavko M, Adeeb S, Conroy MD, Pauly JR, McCarron RM, Sullivan PG. Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury. J Neurosci Res. 2010 Dec;88(16):3530-9. PMID:20882564
  • Small E, Shah HP, Davenport JJ, Geier JE, Yavarovich KR, Yamada H, Sabarinath SN, Derendorf H, Pauly JR, Gold MS, Bruijnzeel AW. Tobacco smoke exposure induces nicotine dependence in rats. Psychopharmacology (Berl). 2010 Jan;208(1):143-58. PMID:19936715
  • Butler TR, Self RL, Smith KJ, Sharrett-Field LJ, Berry JN, Littleton JM, Pauly JR, Mulholland PJ, Prendergast MA. Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience. 2010 Jan 20;165(2):525-34. PMID:19837138
  • Smith AM, Dwoskin LP, Pauly JR. Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences. J Pediatr Biochem. 2010 1 (2): 125-141.
  • Self RL, Smith KJ, Butler TR, Pauly JR, Prendergast MA. Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial learning deficits. Neuroscience. 2009 Oct 20;163(3):868-76. PMID:19619615
  • Kelso ML, Scheff SW, Pauly JR, Loftin CD. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. BMC Neurosci. 2009 Aug 31;10:108. PMID:19719848
  • Pandya JD, Pauly JR, Sullivan PG. The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP. Exp Neurol. 2009 Aug;218(2):381-9. PMID:19477175
  • Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. J Neurosci Res. 2009 May 1;87(6):1462-73. PMID:19021293
  • Pauly JR, Slotkin TA. Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatr. 2008 Oct;97(10):1331-7. PMID:18554275
  • Guseva MV, Hopkins DM, Scheff SW, Pauly JR. Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury. J Neurotrauma. 2008 Aug;25(8):975-83. PMID:18665805
  • Davis LM, Pauly JR, Readnower RD, Rho JM, Sullivan PG. Fasting is neuroprotective following traumatic brain injury. J Neurosci Res. 2008 Jun;86(8):1812-22. PMID:18241053
  • Chin CL, Pauly JR, Surber BW, Skoubis PD, McGaraughty S, Hradil VP, Luo Y, Cox BF, Fox GB. Pharmacological MRI in awake rats predicts selective binding of alpha4beta2 nicotinic receptors. Synapse. 2008 Mar;62(3):159-68. PMID:18081183
  • Pauly JR. Gender differences in tobacco smoking dynamics and the neuropharmacological actions of nicotine. Front Biosci. 2008 Jan 1;13:505-16. PMID:17981564
  • Pandya JD, Pauly JR, Nukala VN, Sebastian AH, Day KM, Korde AS, Maragos WF, Hall ED, Sullivan PG. Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents. J Neurotrauma. 2007 May;24(5):798-811. PMID:17518535
  • Ginzel KH, Maritz GS, Marks DF, Neuberger M, Pauly JR, Polito JR, Schulte-Hermann R, Slotkin TA. Critical review: nicotine for the fetus, the infant and the adolescent? J Health Psychol. 2007 Mar;12(2):215-24.PMID:17284486
  • Guseva MV, Hopkins DM, Pauly JR. An autoradiographic analysis of rat brain nicotinic receptor plasticity following dietary choline modification. Pharmacol Biochem Behav. 2006 May;84(1):26-34. PMID:16753203
  • Kelso ML, Wehner JM, Collins AC, Scheff SW, Pauly JR. The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice. Brain Res. 2006 Apr 14;1083(1):204-10. PMID:16545784
  • Pauly JR, Charriez CM, Guseva MV, Scheff SW. Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease. Ann N Y Acad Sci. 2004 Dec;1035:316-34. PMID:15681815
  • Pauly JR, Sparks JA, Hauser KF, Pauly TH. In utero nicotine exposure causes persistent, gender-dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice. Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):329-37. PMID:15380832
  • Verbois SL, Hopkins DM, Scheff SW, Pauly JR. Chronic intermittent nicotine administration attenuates traumatic brain injury-induced cognitive dysfunction. Neuroscience. 2003;119(4):1199-208. PMID:12831873
  • Verbois SL, Scheff SW, Pauly JR. Time-dependent changes in rat brain cholinergic receptor expression after experimental brain injury. J Neurotrauma. 2002 Dec;19(12):1569-85. PMID:12542858
  • Sparks JA, Pauly JR. Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice. Psychopharmacology (Berl). 1999 Jan;141(2):145-53. PMID:9952038
page last modified: November 22 2013     

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