Patrick McNamara - Ph.D.
Patrick J. McNamara received his Ph.D. in Pharmaceutical Sciences from the State University of New York at Buffalo in 1979. He joined the faculty at the University of Kentucky in 1980 as an assistant professor. Prior to his appointment as chair of the Division of Pharmaceutical Sciences in January 2003, he served as division director for the Division of Pharmaceutics and Pharmaceutical Analysis and for the Division of Pharmacology and Experimental Therapeutics, as well as associate dean for Research and Graduate Studies.
Dr. McNamara has a joint appointment in the Graduate Center for Toxicology and is a member of the Markey Cancer Center. He is a Fellow in American Association of Pharmaceutical Sciences and the American Association for the Advancement of Science. He serves on the Editorial Advisory Board for the Journal of Pharmaceutical Sciences and serves as a reviewer for numerous journals. Dr. McNamara has served as a consultant to a number of pharmaceutical companies.
Dr. McNamara's scholarly interests are in the areas of pharmacokinetics and pharmacodynamics, with a particular emphasis on drug transport. Transport proteins play a pivotal role in facilitating movement of drugs across biological membranes. As such, these proteins can dominate the tissue-specific distribution of drugs, altering their cellular pharmacokinetics and pharmacodynamics. Transporters also may govern the systemic clearance and bioavailability, and thereby, control drug efficacy and toxicity. Dr. McNamara's most recent work has focused on the mechanisms of drug transfer into milk, including transporter gene expression at the blood mammary epithelial barrier. Ongoing research also examines influence of transporters expressed at the blood brain barrier on the penetration of drugs into the CNS. Other projects include modeling the pharmacodynamic of bacterial resistance mechanisms (i.e., up-regulation of efflux transporters and mutations of QRDRs) upon exposure to fluroquinolones. Dr. McNamara's research program utilizes contemporary technology, including cell culture, molecular biology, whole-animal and clinical studies, microdialysis, high-performance liquid chromatography, computer model fitting and simulations.
Selected Publications/Presentations
- Chung, P, McNamara, PJ, Campion, JJ and Evans ME, Comparison of Four Pharmacodynamic Models of Ciprofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 50: 2957-65, (2006).
- Campion JJ, Chung, P, McNamara, PJ, Titlow, W and Evans ME, Pharmacodynamic Modeling of the Evolution of Levofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 49: 2189-99 (2005).
- Edwards JE, Alcorn, MJ, Savolainen J, Anderson BD and McNamara PJ, The Role of p-Glycoprotein in the Distribution of Nelfinavir across the Blood-Mammary Barrier and Blood-Brain Barrier, Antimicrob Agents Chemother 49: 1626-8 (2005).
- Campion JJ, McNamara PJ and Evans ME, Pharmacodynamic Modeling of Ciprofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 49: 209-19 (2005).
- Campion JJ, McNamara PJ and Evans ME, Evolution of Ciprofloxacin-Resistant Staphylococcus aureus in In vitro Pharmacokinetic Environments, Antimicrob Agents Chemother 48: 4733-4744 (2004).
- McNamara, PJ and Abbassi, M, Neonatal Exposure of Drugs in Breast Milk, Pharm Res 21: 555-66 (2004).
- Edwards JE, Rudy, AC, Wermeling, DP, Desai N,and McNamara PJ, The Distribution of Hydromorphone into Human Milk, Pharmacotherapy 23:153-158 (2003).
- Gerk, PM, Moscow, JA and McNamara, PJ, Basolateral Uptake of Nitrofurantoin in the CIT3 Cell Culture Model of Lactation, Drug Metab Dispos 31:691-693 (2003).
- Alcorn, MJ, Moscow, JA, and McNamara, PJ, Transporter Gene Expression in Lactating Mammary Epithelium, J Pharmacol Exper Therap 303: 487-496 (2002).
- Alcorn, MJ, and McNamara, PJ, The Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants: Part II, Clin Pharmacokin 41:1077-1094 (2002).
- Alcorn, MJ, and McNamara, PJ, The Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants: Part I, Clin Pharmacokin 41:959-998 (2002).
- McNamara, PJ and Alcorn, MJ, Protein Binding Predictions in Infants, AAPS PharmSci; 4: article 4 (2002).
- Alcorn, MJ, and McNamara, PJ, Acyclovir, Ganciclovir and Zidovudine Transfer into Rat Milk, Antimicr Agents Chemother 46:1831-1836 (2002).
