Patrick McNamara, Ph.D.
Patrick J. McNamara received his Ph.D. in Pharmaceutical Sciences from the State University of New York at Buffalo in 1979. He joined the faculty at the University of Kentucky in 1980 and has advanced through the academic ranks. Prior to his appointment as Senior Associate Dean for the College of Pharmacy, he served as Director (Division of Pharmaceutics and Pharmaceutical Analysis; Pharmacology and Experimental Therapeutics; and Pharmaceutical Sciences), Chair of the Department of Pharmaceutical Sciences, Associate Dean for Research and Director of Graduate Studies as well as Interim Dean of the College of Pharmacy.
Dr. McNamara has a joint appointment in the Graduate Center for Toxicology and is a member of the Markey Cancer Center. He is a Fellow in American Association of Pharmaceutical Sciences and the American Association for the Advancement of Science. He serves on the Editorial Advisory Board for the Journal of Pharmaceutical Sciences and serves as a reviewer for numerous journals. Dr. McNamara has served as a consultant to a number of pharmaceutical companies.
Dr. McNamara's scholarly interests are in the areas of pharmacokinetics and pharmacodynamics, with a particular emphasis on drug transport into milk and the ontogeny of clearance pathways. Dr. McNamara's most recent work has focused on the mechanisms of drug transfer into milk, including transporter gene expression at the blood mammary epithelial barrier. Ongoing research also examines influence of transporters expressed at the blood brain barrier on the penetration of drugs into the CNS. Other projects include modeling the pharmacodynamic of bacterial resistance mechanisms (i.e., up-regulation of efflux transporters and mutations of QRDRs) upon exposure to fluroquinolones. Dr. McNamara's research program utilizes contemporary technology, including cell culture, molecular biology, whole-animal and clinical studies, microdialysis, high-performance liquid chromatography, computer model fitting and simulations.
- Procter, LD, Meier, CF, Hamilton, C, Gerughty, AR, Overall, P, Santapuram, P, Davenport, PD, McNamara, PJ, Woodward, J, and Bernard, AC. y+ Cationic Amino Acid Transport of Arginine in Packed Red Blood Cells, J Surg Res, 179: e183-87, (2013).
- Kuo, K-L, Zhu, H, McNamara, PJ and Leggas, M, Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues, PLoS One 7(6):e39641 (2012).
- Wang, L, Leggas, M, Empey, PE, Wang, L and McNamara, PJ, Stereoselective Interaction of Pantoprazole with ABCG2: II.. In Vitro Flux Analysis, Drug Metab Dispos 40(5):1024-31 (2012).
- Wang, L and McNamara, PJ, Stereoselective Interaction of Pantoprazole with ABCG2: I. Drug Accumulation in Rat Milk, Drug Metab Dispos 40(5):1018-23 (2012).
- Wang , L, Empey, PE, Goswami, M, Leggas, M and McNamara, PJ, N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a Chemical ATP-binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into Milk. Drug Metab Dispos. 36:2591-6 (2008).
- Alcorn, J, McNamara, PJ. Using Ontogeny Information to Build Predictive Models for Drug Elimination. Drug Discov Today. 13: 507-12 (2008).
- Alcorn, J, Elbarbry F A, McNamara, PJ. Evaluation of the Assumptions of an Ontogeny Model of Rat Hepatic Cytochrome P450 Activity. Drug Metab Dispos 35: 2225-31 (2007).
- Elbarbry, FA, McNamara, PJ, Alcorn, J, Ontogeny of Hepatic CYP1A2 and CYP2E1 Expression in the Rat, J Biochem Mol Toxicol, 21: 41-50 (2007).
- Chung, P, McNamara, PJ, Campion, JJ and Evans ME, Comparison of Four Pharmacodynamic Models of Ciprofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 50: 2957-65, (2006).
- Empey, PE, McNamara, PJ, Young, B, Rosbolt, MB, Hatton, J, Cyclosporin a Disposition Following Acute Traumatic Brain Injury, J NeuroTrauma, 23: 109-16 (2006).
- Campion JJ, Chung, P, McNamara, PJ, Titlow, W and Evans ME, Pharmacodynamic Modeling of the Evolution of Levofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 49: 2189-99 (2005).
- Edwards JE, Alcorn, MJ, Savolainen J, Anderson BD and McNamara PJ, The Role of p-Glycoprotein in the Distribution of Nelfinavir across the Blood-Mammary Barrier and Blood-Brain Barrier, Antimicrob Agents Chemother 49: 1626-8 (2005).
- Campion JJ, McNamara PJ and Evans ME, Pharmacodynamic Modeling of Ciprofloxacin Resistance in Staphylococcus aureus, Antimicrob Agents Chemother 49: 209-19 (2005).
- Campion JJ, McNamara PJ and Evans ME, Evolution of Ciprofloxacin-Resistant Staphylococcus aureus in In vitro Pharmacokinetic Environments, Antimicrob Agents Chemother 48: 4733-4744 (2004).
- Davis, GA, Rudy, AC, Archer, SM, Wermeling, DP and McNamara PJ, Bioavailability and Pharmacokinetics of Intranasal Hydromorphone in Patients Experiencing Vasomotor Rhinitis, Clinical Drug Investigation 24: 633-639 (2004).
- Davis, GA, Rudy, AC, Archer, SM, Wermeling, DP and McNamara PJ, Effect of Fluticasone Propionate Nasal Spray on Bioavailability of Intranasal Hydromorphone Hydrochloride in Patients with Allergic Rhinitis, Pharmacotherapy 24:26-32 (2004).
- McNamara, PJ and Abbassi, M, Neonatal Exposure of Drugs in Breast Milk, Pharm Res 21: 555-66 (2004).
- Edwards JE, Rudy, AC, Wermeling, DP, Desai N,and McNamara PJ, The Distribution of Hydromorphone into Human Milk, Pharmacotherapy 23:153-158 (2003).
- Gerk, PM, Moscow, JA and McNamara, PJ, Basolateral Uptake of Nitrofurantoin in the CIT3 Cell Culture Model of Lactation, Drug Metab Dispos 31:691-693 (2003).
- Alcorn, MJ, and McNamara, PJ, Pharmacokinetics in the Newborn, Adv Drug Delivery Rev. 455: 667-86 (2003).
- Savolainen J, Edwards JE, Morgan ME, McNamara PJ, Anderson BD, Effects of a P-Glycoprotein Inhibitor on Brain and Plasma Concentrations of Anti-Human Immunodeficiency Virus Drugs Administered in Combination in Rats, Drug Metab Dispos. 30(5):479-82 (2002).
- Alcorn, MJ, Moscow, JA, and McNamara, PJ, Transporter Gene Expression in Lactating Mammary Epithelium, J Pharmacol Exper Therap 303: 487-496 (2002).
- Alcorn, MJ, and McNamara, PJ, The Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants: Part II, Clin Pharmacokin 41:1077-1094 (2002).
- Alcorn, MJ, and McNamara, PJ, The Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants: Part I, Clin Pharmacokin 41:959-998 (2002).
- Edwards, J, Brouwer, KR and McNamara, PJ, GF120918, an MDR Modulator, Increases the Unbound Concentration of Amprenavir in the CNS, Antimicr Agents Chemother 46:2284-2286 (2002).
- McNamara, PJ and Alcorn, MJ, Protein Binding Predictions in Infants, AAPS PharmSci; 4: article 4 (2002).
- Alcorn, MJ, and McNamara, PJ, Acyclovir, Ganciclovir and Zidovudine Transfer into Rat Milk, Antimicr Agents Chemother 46:1831-1836 (2002).
- Gerk, PM, Hanson L, Neville, MC and McNamara, PJ, Sodium Dependence of Nitrofurantoin Active Transport Across Mammary Epithelia and Effects of Dipyridamole, Nucleosides, and Nucleobases, Pharm Res 19: 299-305 (2002).
- Savolainen J, Edwards JE, Morgan ME, McNamara PJ, Anderson BD, Effects of Co-Administration of 6-Cl-ddP, Nelfinavir and GF120918 on Brain and Plasma Distribution of 6-Cl-ddP, Didanosine and Nelfinavir in Rats After Intravenous Administration Drug Metab Dispos 30:479-82 (2002).