We study mechanisms required for the pathogenesis of infection and discover novel compounds to inhibit these mechanisms by using a combination of enzymology, structural biology and biophysical chemistry.
Latest News from the Lab
We have immediate openings for graduate and undergraduate students. Graduate students should first apply to the Ph.D. Program in Pharmaceutical Sciences at the University of Kentucky.
- Our manuscript on the crystal structure inorganic pyrophosphatase from Staphylococcus aureus is accepted for publication in the Journal of Structural Biology. Congratulations, Chathurada!
- Dimitri Leggas becomes a national semifinalist in the prestigious 2014 Siemens Competition among high-school students doing research for his project in our group on development a novel mathematical method of determining crystal structures. He is one of 400 semifinalists selected out of ~4,500 students who entered the competition this year. Congratulations, Dimitri! Please, see Press Releases from the Gatton Academy and the UK College of Pharmacy for more information.
- Our manuscript on DNA intercalator inhibitors of M. tuberculosis primase DnaG is accepted for publication in the Journal of Antibiotics. Congratulations to Chathurada, Keith from Sylvie Garneau-Tsodikova's group, Jamie Posey, Melisa Willby, Micha Fridman and Pazit Shaul!
- We welcome Dr. Allan Pang, a new Postdoctoral Scholar in our group
- We welcome Grace Johnson, a UK undergraduate who will be studying drug-DNA interactions by X-ray crystallography
- We say goodbye to Sandi, who is moving to Washington D.C. to start a permanent government laboratory position. Good luck, Sandi !
- We welcome Dr. Chathurada Gajadeera, a new Postdoctoral Scholar in our group
- We welcome Abraham Dutch, an undergraduate student who joins the group to work in computational crystallography
- We welcome Nick Winquist, a graduate student in Pharmaceutical Sciences Graduate Program, who joins the lab to do a rotation project
- Our manuscript on the discovery of inhibitors of Bacillus anthracis primase in collaboration with Dr. Garneau-Tsodikova's group is accepted for publication in Biochemistry. Congratulations to Tapan and Keith!
- We welcome Zheng Cui, a graduate student in Pharmaceutical Sciences Graduate Program, who joins the lab to do a rotation project
- We welcome Dr. Caixia Hou, a research scientist in the group