Elimination – Cobalt (Co)
Fecal excretion, the major route
of Co excretion in humans, was effected by the species of Co given. Fecal
clearance increased with increasing particle size and decreasing solubility.
Fecal excretion of Co from the insoluble cobaltic-cobaltous oxide (Co3O4) was
> 96% whereas it was 70-83% of the more soluble Co chloride
(Ayala-Fierro et al., 1999;
Bailey et al., 1989). Dogs
excreted 90% of the Co from Co3O4 in the feces whereas 70% of the Co from Co
Co chloride was eliminated more
rapidly then Co protoporphyrin.
Link to Elimination
Link to Database Index